Parkinsondisease相关论文
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目的:探讨耐力训练对帕金森病(Parkinson disease，PD)模型小鼠的保护作用以及通过AMPK/mTOR通路对自噬和外泌体途径的影响。方法:选......
目的:观察帕金森病(Parkinson\'s disease，PD)合并剂峰异动患者的静息态脑活动特点，并探索其发病机制。方法:招募2017年3月至2019......
脑白质病变(white matter lesions，WMLs)是由多种病因引起的脑室周围及皮质下的广泛脑白质损害。既往研究表明，WMLs与认知功能、运动......
牙周病是由细菌引起的牙支持组织的疾病，可导致全身的慢性低度炎症。一旦全身慢性炎症持续存在，可能诱发神经炎症。神经炎症是多种神......
帕金森病(PD)是一种隐匿性和进行性发展的神经退行性疾病,在65岁以上人口中约占2％～3％,是第二大常见的神经退行性疾病.PD的致病因素尚......
目的:分析血清α-突触核蛋白(α-syn)、微小核糖核酸-214(miR-214)联合检测在帕金森病(PD)患者认知功能障碍评估中的应用价值。方......
目的:观察腹腔注射百草枯（PQ）构建的帕金森（PD）小鼠模型的肠道时间依赖性改变，初步建立脑肠轴的联系。方法:于2019年10月，将48只小鼠随机......
目的:评价自拟停颤汤联合多巴丝肼片治疗中早期帕金森病（Parkinson disease，PD）阴虚风动证临床疗效。方法:将符合入选标准的2020年1月......
目的:分析帕金森病患者立体定向脑核团毁损术后发生谵妄的影响因素。方法:回顾性分析2018年12月至2021年2月解放军第八十三集团军......
Effect of Roucongrong (Herba Cistanches Deserticolae) decoction on the substantia nigra through Wnt/
OBJECTIVE:To investigate the effect of Roucon-grong (Herba Cistanches Deserticolae) decoction on the substantia nigra in......
Converging lines of evidence demonstrate that intracellular accumulation of α-synuclein(α-Syn)as filamentous aggregate......
α-Synuclein(α-Syn)is the most abundant protein found in Lewy bodies,a hallmark of Parkinsons disease(PD).Pathological ......
Brain network variations of patients with Parkinson disease between before and after dopamine condit
Dopaminergic drugs are effective to patients with Parkinson disease.Explanation of the brain network variation between b......
Tetrahydroxystilbene glucoside protects LPS-induced dopaminergic neurodegeneration via the inhibitio
Aim: Parkinson disease (PD) is one of the most common neurodegenerative diseases characterized by progressive dopaminerg......
Dihydromyricetin protects neurons in MPTP-induced Parkinson disease via suppressing activity of glyc
OBJECTIVE Parkinson disease(PD)is a neurodegenerative disease characterized by the selective loss of dopaminergic neuron......
FCPR16 induces AMPK-dependent autophagy and provides neuroprotection in SH-SY5Y cells and neurons ex
OBJECTIVE The cause of Parkinson disease(PD)is generally not clear,but it is considered to be related to excessive oxida......
Naringenin protects against 6-OHDA-induced neurotoxicity via activation of the Nrf2/ARE signaling pa
OBJECTIVE To investigate the neuroprotective role of naringenin and delineate its mechanism of action against 6-hydroxyd......
Parkinsons disease (PD) is a chronic progressive neurodegenerative disease which was first described in 1817, affecting ......
Effects of Rigidity on the Flexibility and Stability of Interlimb Coordination during Walking in Par
Background.Rigidity is one of the cardinal signs of Parkinsons disease (PD), which has been associated with the reduced ......
HDAC6 regulates aggresome-autophagy degradation pathway of α-synuclein in response to MPP+-induced s
Increasing evidence suggests that the ubiquitin-binding histone deacetylase-6 (HDAC6) plays an important role in the cle......
Objective To explore the diagnostic value of magnetic resonance spectroscopy(MRS) on idiopathic Parkinson disease with u......
Quantitative autonomic function test in differentiation of multiple system atrophy from idiopathic P
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Long-term Efficacy of Subthalamic Nucleus Deep Brain Stimulation in Parkinson’s Disease: A 5-year Fo
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目的探讨尾侧未定带脑深部电刺激术(cZI-DBS)治疗运动障碍性疾病的疗效及安全性。方法回顾性分析2020年9—12月首都医科大学附属北......
目的探讨原发性帕金森病患者疼痛症状的临床特征及影响因素。方法采用国王帕金森病疼痛量表（KPPS）对2018年5月至2020年11月在安徽医......
帕金森病是一种具有特征性运动症状的神经系统变性疾病，由于其疾病负担日益加重，在全球范围内都受到广泛关注。目前其诊断、鉴别诊断......
帕金森病非运动症状目前越来越受到重视，也成为研究帕金森病的热点。文中介绍了帕金森病相关非运动症状包括感觉障碍、神经精神症状......
目的探讨卡巴拉汀联合司来吉兰治疗帕金森病(PD)的疗效及对血清β淀粉样蛋白1-42(Aβ1-42)、胰岛素样生长因子-1(IGF-1)水平的影响......
Epimedium Brevicornum is a traditional Chinese medicinal plant possessing properties of sweet,warm,tonifying kidney,......
目的深入了解帕金森病患者的消化道症状谱特征，以助于帕金森病消化道症状的早期识别和疾病管理。方法连续纳入2017年1—8月就诊于北......
目的探讨帕金森病（PD）患者抑郁发生情况及其相关因素。方法连续纳入2019年3－6月在北京医院神经内科门诊就诊的100例帕金森病（PD）患者，采......
帕金森病是近年来我国发病率和患病人群逐年增加的第二大神经退行性疾病，其诊断和治疗相对困难，目前尚不能治愈，给患者家庭和社会都带......
目的评价丙泊酚对帕金森病(PD)小鼠黑质炎症反应的影响及其与α-突触核蛋白(α-syn)表达的关系。方法SPF级健康雄性C57BL/6小鼠33......
将稳定转染了大鼠酪氨酶羟化酶基因的大鼠成肌细胞移植于帕金森病大鼠模型模型的纹状体，进行基因治疗研究，ＲＴ－ＰＣＲ和免疫组织化学检测都证明......
帕金森病（PD）是一种由于中脑的黑质神经元变性坏死所导致的神经系统疾病,属中医＂颤证＂范畴。目前西药治疗虽能在初期改善症状,但部分病......
目的探讨PET在体显示移植于帕金森病（PD）大鼠模型脑内的视网膜色素上皮（RPE）细胞分化结果及治疗效果。方法将RPE细胞移植于治疗组PD模......
神经炎性反应是包括帕金森病(PD)在内的许多神经退行性疾病的重要病理改变之一，小胶质细胞的激活为中枢神经系统炎性反应的主要特征......
目的探讨α-突触核蛋白中2个位点单核苷酸多态性(rs356219、rs356165)与帕金森病认知功能障碍的相关性。方法随机抽取2014年11月至......
目的调查帕金森病患者的坚韧性人格与生存质量的水平，并分析二者的相关性。方法选取2017年2月～5月在大连医科大学附属第一医院住院及......
Analysis of brain-stem auditory evoked potential and visual evoked potential in patients with Parkin
BACKGROUND: With the development of neuroelectrophysiology, it had been identified that all kinds of evoked potentials m......
Changes of dynamical balance of free radicals induced by levodopa in rat glia-containing mesencephal
BACKGROUND: Parkinson disease is neurodegenerative disorders, characterized by a progressive and selective degeneration ......
